Uses
Insomnia:
Nitrazepam is primarily used for the short-term treatment of severe insomnia, especially when difficulty falling or staying asleep is affecting daily functioning.
Seizure Disorders:
It may be used in the management of certain types of epilepsy, particularly in children, as an anticonvulsant.
Mechanism of Action
Nitrazepam works by enhancing the effect of gamma-aminobutyric acid (GABA) in the brain. GABA helps slow down nerve activity, producing a calming effect that promotes sleep and reduces excessive brain activity linked to seizures.
Side Effects
Common side effects may include:
Less common but serious side effects can include:
Caution
Dependence:
Long-term use can lead to physical and psychological dependence.
Withdrawal:
Abrupt discontinuation may cause rebound insomnia, anxiety, irritability, or seizures. Dose reduction should be gradual under medical supervision.
Interactions:
Nitrazepam should not be combined with alcohol, opioids, or other central nervous system depressants, as this can increase the risk of severe sedation and respiratory depression.
Administration
Nitrazepam 5mg should be taken exactly as prescribed by a healthcare professional, usually at bedtime. It is intended for short-term use only. Regular medical review is important to ensure safe and effective treatment.


